Evaluating drug-drug interaction information in NDF-RT and DrugBank
نویسندگان
چکیده
منابع مشابه
Evaluating drug-drug interaction information in NDF-RT and DrugBank
BACKGROUND There is limited consensus among drug information sources on what constitutes drug-drug interactions (DDIs). We investigate DDI information in two publicly available sources, NDF-RT and DrugBank. METHODS We acquire drug-drug interactions from NDF-RT and DrugBank, and normalize the drugs to RxNorm. We compare interactions between NDF-RT and DrugBank and evaluate both sources against...
متن کاملEvaluating NDF-RT
The National Drug File Reference Terminology (NDF-RT) presents a large set of drug classes which can potentially be used in clincal settings. Using semantic web technologies such as XML (eXtensible Markup Language) and RDF (Resource Description Framework), the drug classes in NDF-RT were enriched for the purpose of comparison to themselves and to drug classes in other terminologies. Methods and...
متن کاملPharmGKB Drug Data Normalization with NDF-RT
The Pharmacogenomics Knowledge Base (PharmGKB) [1] is a publicly available central resource for pharmacogenomics data and knowledge, which is being widely employed into clinical practice and thus requires using clinical terminologies. Hence, harmonizing PharmGKB drug data with well annotated drug terminologies will facilitate its integration with other related resources and support data represe...
متن کاملEvaluating the consistency of inferred drug-class membership re- lations in NDF-RT
Objectives: To evaluate the consistency of inferred drugclass membership relations in NDF-RT (National Drug File Reference Terminology). Methods: We use an OWL reasoner to infer the drug-class membership relations from the class definitions and the descriptions of drugs and compare them to asserted relations. Results: The inferred and asserted relations only match in about 50% of the cases. Con...
متن کاملAnalyzing categorical information in two publicly available drug terminologies: RxNorm and NDF-RT
BACKGROUND The RxNorm and NDF-RT (National Drug File Reference Terminology) are a suite of terminology standards for clinical drugs designated for use in the US federal government systems for electronic exchange of clinical health information. Analyzing how different drug products described in these terminologies are categorized into drug classes will help in their better organization and class...
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ژورنال
عنوان ژورنال: Journal of Biomedical Semantics
سال: 2015
ISSN: 2041-1480
DOI: 10.1186/s13326-015-0018-0